Cancer Bone Metastases & Skeletal Related Events

Bone resorption related complications are the most common metabolic complications associated with cancers, and most of these are grouped as skeletal related events (SREs). SREs are most commonly associated with bone metastases. They encompass all the bone related outcomes including bone fractures, spinal cord compression and bone pain. Bone metastases are the most common site of metastases for cancers, and detected in 75% of all metastatic cancers [1]. The US incidence of bone metastases is 400,000 [2] and the global incidence is 1.5M [3].


  1. Incidence, consequences and treatment of bone metastases in breast cancer patients—Experience from a single cancer centre. (2013). Journal of Bone Oncology, [online] 2(4), pp.137-144. Available at: [Accessed 12 Apr. 2018].
  2. Coleman, R., Lipton, A., Roodman, G., Guise, T., Boyce, B., Brufsky, A., Clézardin, P., Croucher, P., Gralow, J., Hadji, P., Holen, I., Mundy, G., Smith, M. and Suva, L. (2010). Metastasis and bone loss: Advancing treatment and prevention. Cancer Treatment Reviews, [online] 36(8), pp.615-620. Available at: [Accessed 12 Apr. 2018].
  3. Coleman, R., Major, P., Lipton, A., Brown, J., Lee, K., Smith, M., Saad, F., Zheng, M., Hei, Y., Seaman, J. and Cook, R. (2005). Predictive Value of Bone Resorption and Formation Markers in Cancer Patients With Bone Metastases Receiving the Bisphosphonate Zoledronic Acid. Journal of Clinical Oncology, [online] 23(22), pp.4925-4935. Available at: [Accessed 12 Apr. 2018].